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After a series of suspicious murders in Washington, D.C., Prentiss suspects her old Interpol archenemy may be involved in the crimes, which makes her fear for the safety of her team as he closes in on her.
- Jim Castillo - Himself
- John Colella - Ron Cosenza
- Thor Edgell - Byron Delaney
- Siena Goines - Tsia Mosely
- Brian D. Johnson - Frank Fagan
- Madison Mason - Lex Dreyer
- Andy McPhee - Liam
- Jan Munroe - Doctor Sherman
- Timothy V. Murphy - Ian Doyle
- Fionn William O'Brien - Calum
- Tyler Poelle - Jeff Hastings
- Jennifer Riker - Kerry Fagan
- Sebastian Roché - Clyde Easter
- Desary Vailencour - BAU Agent
- Emily Prentiss: Lao Tzu said, "When I let go of what I am, I become what I might be."
- Emily Prentiss: Journalist Dorothy Dix wrote, "Confession is always weakness. The grave soul keeps its own secrets and takes its own punishment in silence."
- Tyler Poelle, the actor who portrays Jeff Hastings, previously appeared on Criminal Minds, starring as Officer Joe in the Season Three premiere episode "Doubt".
- Credited as "Weatherman"