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When a friend of Stephen's is among several federal government employees to die of apparent heart attacks, the BAU investigates to see if there is more to their deaths. Also, Reid begins to worry about his trial.
- Morgan Alexandria - Nurse
- Darren Barnet - Zach Bower
- Hart Bochner - Sam Bower
- Eric Deskin - Alex McLean
- Ramona DuBarry - Doctor
- Jeananne Goossen - Fiona Duncan
- Travis Greer - Officer Butler
- Antonia Jones - Lisa Bower
- Jane Lynch - Diana Reid
- Gia Mantegna - Lindsey Vaughn
- Tracie Thoms - Monica Walker
- Ilia Volok - Dmitri Sobchek
- Fanny Kaplan
- The Georgi Markov case
- The Viktor Yushchenko case
- The Alexander Litvinenko case
- The September 11 Hijackers
- "Birth of a Hero" by Two Steps From Hell
- Stephen Walker: "The past is never where you think you left it." – Katherine Anne Porter
- Spencer Reid: "Life can only be understood backwards, but it must be lived forwards." – Søren Kierkegaard
- This is the ninth of nine episodes to deal with two separate cases.