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The BAU meets their new section chief, Mateo Cruz, who, unbeknownst to them, shares a long work history with JJ. Cruz joins the team as they comb the streets of Baltimore for an abductor who leaves victims unable to communicate.
- David Anders - Anton Harris
- Brian Appel - Agent Grant Anderson
- Daren Dukes - Truck Driver
- Franklin Killian - Sam Carter
- Esai Morales - FBI Section Chief Director Mateo Cruz
- Emily Podleski - Dana Harris
- Charles Rahi Chun - Doctor Hoshino
- Martin Thompson - Aldor Harris
- Jeffrey Dahmer, The Milwaukee Cannibal
- Derek Morgan: "Someone I loved once gave me a box full of darkness. It took me years to understand that this too was a gift." — Mary Oliver
- Aaron Hotchner: "Death is not the greatest loss in life. The greatest loss is what dies inside of us while we live." — Norman Cousins
- Though this was the fourth episode to air, this was the third produced episode.