When teenagers who were reported missing are now suspected of a series of random, violent terrorist attacks in Chicago, the BAU investigates their whereabouts to find a motive for the crimes. Also, Morgan has conflicting feelings when his girlfriend takes her job at a hospital as seriously as he takes his.
- A.J. Achinger - Daniel James Morrison
- Rochelle Aytes - Savannah Hayes
- Ronnie Banks - Gavin Rossler
- Jan Broberg - Lauren Morrison
- Jimmy Carlson - Reporter
- Maurice Compte - Detective Mark Reyes
- Alexander Eckert - Cameron Patterson
- Andrew Fiscella - Officer Ryan Clayburn
- Kelly Hawthorne - Sylvia Hoover
- Koby Kumi-Diaka - Trevor Madison
- Rob Lavin - Bomb Squad Agent
- Silawn Lewis - Pedestrian
- Gwen McGee - Doctor Taylor
- Steve Rizzo - Traffic Cop
- Karly Rothenberg - Leah Rollins
- Mark Sivertsen - Wayne Gulino
- Emily Skinner - Julie Hoover
- Joanna Tiwald - Stephanie Lawford
- "Minute By Minute" by The James Hunter Six
- "Hold Me Sweetly" by Monet Cherise
- Derek Morgan: Alfred Hitchcock said, "There's no terror in the bang, only the anticipation of it."
- Jennifer Jareau: "The greater the power, the more dangerous the abuse." — Edmund Burke
- Jan Broberg, the actress who portrays Lauren Morrison, was once abducted by a family friend who was a pedophile and "brainwashed" her into staying with him. Her appearance in the episode may have been an allusion to the details of her childhood abduction.