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The BAU investigates the murders of several homeless men in San Francisco and coordinates their efforts with another team of BAU agents who are working on a series of murders of father-daughter duos that appears to be connected.
- Jayne Atkinson - FBI Section Chief Director Erin Strauss
- Jason Brooks - John Vincent Bell
- Scott Allan Campbell - Detective Ganz
- Lesley Fera - Leslie McBride
- Beau Garrett - SSA Gina LaSalle
- Eric B. Gerlemen - Suspect
- Michael Kelly - SSA Jonathan "Prophet" Simms
- Howard S. Miller - Coroner
- Alexa Nikolas - Jane McBride
- Matt Ryan - SSA Mick Rawson
- Felix Solis - Nelson G.
- Forest Whitaker - SSA Sam Cooper
- Jason Wiles - Ben McBride
- Kelvin Han Yee - Detective Ekler
- Aaron Hotchner: Mother Teresa said, "I have found the paradox, that if you love until it hurts, there can be no more hurt, only more love."
- This episode is the backdoor pilot for the short-lived spin-off series, Criminal Minds: Suspect Behavior, created by Chris Mundy and Edward Allen Bernero (the writers of this episode).
- Jason Wiles, the actor who portrays Ben McBride, previously appeared on an earlier episode of Criminal Minds, appearing in the Season Two episode "Psychodrama," in which he portrayed bank robber and budding spree killer Caleb Dale Sheppard.