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- Matthew Alan Brady - Lionel
- Emayatzy E. Corinealdi - Ellen Samsen
- Steven Dady - Son
- Aasha Davis - Daria Samsen
- Mark DeSalvo - Police Officer
- Aaron Fili - Medical Examiner Garrison
- Marty Fortney - Dad
- Taymour Ghazi - Joe Bachner
- Lisa Kaminir - Doctor Carol Roberts
- Mandi Kreisher - Carrie
- Caroline Lindy - Melissa Coleman
- Guy Nardulli - Detective Walker
- Anthony Nuccio - Coby Peters
- Scott Speiser - Doctor Claude Pinault
- Sunny Suljic - Young Joe Bachner
- Isabella Way - Nurse
- "Undermined (Scratch Mix)" by Mellisa R. Kaplan & Jeff Toyne
- Derek Morgan: "No one is ever a victim, although your conquerors would have you believe in your own victimhood. How else could they conquer you?" Barbara Marciniak
- Derek Morgan: "There are times when the mind is dealt such a blow it hides itself in insanity. There are times when reality is nothing but pain and to escape that pain, the mind must leave reality behind." Patrick Rothfuss
- The first name of Coby Peters and the surname of Joe Bachner may have been chosen as an homage to "Remembrance of Things Past" (which featured a character named Colby Bachner and revolved around a two-person killing team), which was the first episode written for the show by Janine Sherman Barrois.
- Guy Nardulli, the actor who portrays Detective Walker, previously appeared on Criminal Minds in the Season Three episode "The Crossing," starring as an undercover cop.