When mummified remains of numerous victims are found inside an elderly couple's home in South Carolina, the BAU is called in to investigate and track a serial killer. Meanwhile, Rossi reconnects with Krystall.
- Rosemary Alexander - Dorothy Elgin
- Mashari Laila Bain - Medical Examiner Theresa Caldwell
- Libby Baker - Mary Brewer
- Khalif Boyd - Ben Hicks
- Seychelle Brown - Laura Burgess
- Mary Elizabeth Boylan - Cindy Underwood
- Drew Cash - Scott Gillen
- Christopher Darga - Sheriff Wesley Hayes
- Olivia DiNino - Penny Cumbre
- Gracie Lane - Delta Coughlan
- Archer Moller - Young Unsub
- Gail O'Grady - Krystall Richards
- Niko Papastefanou - Unsub
- Lara Phillips - LeeAnne Garrity
- Danielle C. Ryan - Portia Richards
- Janet Song - Lydia Garland
- Amanda Westlake - Ella Hicks
- "Comin' Back for More" by Leopard Lounge Groove
- David Rossi: "Memory is a crazy woman that hoards colored rags and throws away food." – Austin O'Malley
- Jennifer Jareau: "Without a family, man, alone in the world, trembles with the cold." – Andre Maurois
- The closing bookend quote recited by JJ was previously recited by Rossi in the Season Four episode "A Shade of Gray."
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