The BAU travels to the Midwest to track down a spree killer who is targeting families in Nebraska and Iowa. Meanwhile, a troubled Ellie Spicer runs away from her foster family to visit Morgan in Quantico.
- Sterling Beaumon - Jeremy Sayer
- Michael Reilly Burke - Agent Grady Beeks
- Kristin Carey - Sandra Bennett
- William Cowart - Reverend Louis Hannum
- Chloe Csengary - Carrie Sayer
- Evan Dye - Zack Riverton
- David Goryl - Jake Bennett
- Stephanie Katherine Grant - Amber Riverton
- Natalie Alyn Lind - Kayla Bennett
- Kenneth Meseroll - State Trooper
- Cameron Meyer - Ellie's Mom
- Isabella Murad - Ellie Spicer
- Kerry O'Malley - Kendra Sayer
- Preston Strother - Sammy Bennett
- Mare Winningham - Nancy Riverton
- "Moneygrabber" by Fitz and the Tantrums
- "In One Ear" by Cage the Elephant
- "Waltz C Minor Op 64" by APM
- "System Overload" by the P Jayz
- "Cooler Than Me" by Mike Posner
- "House of Wax" by Wax Tailor
- "Why Don't You Love Me" by the Dahls
- "Nobody Hot As Me" by KU
- Derek Morgan: "All humanity is one undivided and indivisible family. I cannot detach myself from the wickedest soul." Mahatma Gandhi
- Derek Morgan: "But I have promises to keep, and miles to go before I sleep, and miles to go before I sleep." Robert Frost
- Interestingly enough, Sterling Beaumon, the actor who portrays the episode's unsub, would later go on to portray Hunter Mazelon, the main antagonist of the 23rd episode of Season Twelve on Law & Order: Special Victims Unit. Both characters are very similar - Both are psychopathic and murderous teenage boys, have some sexual element in their crimes (Jeremy's is unspecified), have an intense hatred of their mothers, and used knives to kill at least one of their victims. It's likely that Sterling's performance as Jeremy influenced his as Hunter (as well as the episode in general).
- Michael Reilly Burke, who portrays FBI agent Grady Beeks, has previously portrayed real-life serial killer Ted Bundy in the 2002 movie of the same name.
- "Safe haven" is an alternate term for a sanctuary. It can also be used to refer to the safe-haven law, which is referenced in the episode.
- Kenneth Meseroll, the actor who portrayed a state trooper, previously appeared in an earlier episode of Criminal Minds, starring as Mayor Gregory Hughes in the Season Two episode "Fear and Loathing."
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