When several women in Virginia are found murdered in a similar manner, Rossi reopens an unsolved cold case in Bristol that has haunted him for a quarter of a century because he believes the original killer might have returned.
- Josh Braaten - Colby Bachner
- Hunter Drago - Pharmacy Customer
- Mary Beth Evans - Candice DeLilly
- Megan Gallacher - Jenny DeLilly
- Ellie Gerber - Heather Langley
- Mark Hutter - Mr. Langley
- Cristen Irene - Anna
- Michael Ketzner - Young Colby Bachner
- Ashley Morgan Kilbride - Butcher Victim
- Michael Lesly - Officer
- Nan McNamara - Mrs. Langley
- Renato Powell - Jocelyn Sherman
- T. Shaun Russell - Prison Guard
- Heather Simpson - Karen Bachner
- Marissa Skell - Shelly
- David Rees Snell - Detective Green
- Michael Spound - Sam DeLilly
- Daniel J. Travanti - Lee Mullens
- Mateus Ward - Lyle DeLilly
- Josh Woodle - Michael Young
- Ray and Faye Copeland
- The September 11 Hijackers
- Jack the Ripper
- Ted Bundy
- Jeffrey Dahmer, The Milwaukee Cannibal
- Dennis Rader, BTK
- Lonnie David Franklin, The Grim Sleeper
- David Rossi: Marcel Proust wrote, "Remembrance of things past is not necessarily the remembrance of things as they were."
- David Rossi: Mark Twain wrote, "When I was younger I could remember anything, whether it had happened or not. But my faculties are decaying now... and soon I shall be so I cannot remember anything but the things that never happened. It is sad to go to pieces like this, but we all have to do it."
- Ashley Morgan Kilbride, the actress who portrayed a murder victim, also portrayed Amy Sherigan in an episode of Suspect Behavior, the short-lived Criminal Minds spin-off.
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