Disambiguation: This page is about the episode. For the person, see Penelope Garcia
- Jon Barton - SWAT Leader
- Nicholas Brendon - Analyst Kevin Lynch
- Bailey Chase - Deputy Jason Clark Battle
- Maddison Davis - Young Penelope Garcia (Age 5)
- Reena Dutt - Nurse
- John Eddins - Detective Walker
- Rebecca Egender - Young Penelope Garcia (Age 20)
- Christina Gabrielle - Young Penelope Garcia (Age 9)
- Sabrina Gennarino - Medic #2
- Loren Lester - Surgeon #2
- James Kalagher - Waiter
- Bruce Katzman - Trauma Surgeon
- Anne McCarthy - ER Nurse
- Andrew Elvis Miller - Medic #1
- Mati Moralejo - Officer Mike Fleming
- Marc Vann - IA Agent Adam Fuchs
- Paul Vroom - Clerk
- Tamara Zook - Neighbor
- "Virtually Happy" by Holly Golightly
- "Heroes" by David Bowie
- Penelope Garcia: William Shakespeare wrote, "Love all, trust a few, do wrong to none."
- Garcia's password to the encrypted file on her computer is "Gilman Street". This is most likely a reference to the music club located in Berkeley, California. It typically showcases punk rock, a music genre Garcia is possibly a fan of.
- Andrew Elvis Miller and Sabrina Gennarino, who portray medics in this episode, previously portrayed a pair of other medics in the Season Two premiere episode "The Fisher King, Part 2".
- Nicholas Brendon and Bailey Chase, who portrayed Kevin Lynch and Jason Clark Battle respectively, were also both featured on Buffy the Vampire Slayer, Brendon playing Xander Harris and Chase playing Graham Miller.