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- Mark St. Amant - Jake Hillridge
- Alton Clemente - Deputy
- Bud Cort - Roger Roycewood
- Ann Cusack - Sarah Hillridge
- Beth Grant - Anita Roycewood
- Toby Huss - Frank Lynch
- Richard Clarke Larsen - Mr. Hayden
- Bunny Levine - Martha Woodley
- Katlin Mastandrea - Mae Hall
- Austin Mincks - Stephen Shepherd
- Evan Peters - Charlie Hillridge
- Cameron Protzman - Aimee Lynch
- Grace Savage - Jane
- Brooke Smith - Barbara Lynch
- Debra Sullivan - Mrs. Shepherd
- Owen Thayer - Police Sketch Artist
- Holly Traister - Imaginary Female Unsub
- David Youse - Mr. Shepherd
- "Illabye" by Tipper
- "Omberg" by Frederik
- Jennifer Jareau: Nietzsche wrote, "Hope is the worst of evils, for it prolongs the torment of man."
- Jennifer Jareau: Emily Dickinson wrote, "Hope is the thing with feathers, that perches in the soul, and sings the tune without words, and never stops at all."
- This episode marks the first time in the show's history where a member of the main cast, Matthew Gray Gubler, has directed an episode. He would be followed by Thomas Gibson, Joe Mantegna, Aisha Tyler, Adam Rodriguez, and A.J. Cook.
- Bunny Levine, the actress that played Martha Woodley, previously appeared on Criminal Minds, starring as Sylvia Cohen in the Season Two episode "Empty Planet".
- Sarah Hillridge is similar to Noreen Gosch, the real-life mother of a missing boy, Johnny Gosch. Noreen claimed that she saw her son, alive, several years after he had been kidnapped. Johnny Gosch has never been found.
- In the episode, the dates of three of the victims' abductions are listed a year later on the BAU's bulletin board than they are on Garcia's computer screen. This is most likely an error on the designer's part.
- Credited as "News Anchor"