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After a bomb explodes an SUV in New York City that might be carrying a BAU member, the team goes into high gear to determine who might have been injured in the explosion and to apprehend the terrorists responsible for the mayhem.
- Zac Alexander - Doctor Marino
- Joe Basile - Colm Lagan
- Greg Collins - Captain Warner
- Moe Daniels - Lisa Bartleby
- Amie Farrell - Agent Shelly Davis
- Sienna Guillory - SSA Kate Joyner
- Brandon Hirsch - ESU Two
- Loren Lester - Doctor Shore
- Adoni Maropis - Ben Abner
- Jack McGee - Detective Brustin
- Erik Palladino - Detective Cooper
- Geoff Reeves - ESU One
- Michael Steger - Sam
- Monica Young - News Reporter
- The September 11 Hijackers
- The London Bombers (Yasin Hassan Omar, Osman Hussain, Muktar Said Ibrahim, and Ramzi Mohammed)
- Azahari Husin, The Demolition Man
- "Mr. Lonely" by Bobby Vinton
- Aaron Hotchner: "Never think that war, no matter how necessary, nor how justified, is not a crime." – Ernest Hemingway
- Loren Lester, the actor who portrays Doctor Shore, previously appeared in Criminal Minds, starring in the Season Three episode "Penelope" as a surgeon.
- A truck with the name "Bernero Hospital Linens" can be seen in the background of one particular scene, in reference to executive producer Edward Allen Bernero.