- Jason Alexander - Henry Grace
- Jon Barton - SWAT Leader
- Quonta Beasley - Student #2
- Nicholas Brendon - Analyst Kevin Lynch
- Davis Cleveland - Ricky
- Tiffany Espensen - Samantha
- Brighid Fleming - Jessica
- Paul Michael Glaser - Detective Garrity
- Meta Golding - Agent Jordan Todd
- Jamie Israel - Student #1
- Ali Landry - Kaylee Robinson
- Kathryn Ruel - College Girl
- Gina Garcia Sharp - CSU Tech Agent Gina Sharp
- Ellery Sprayberry - Chelsea Robinson
- Nic Wegener - Harrison
- David Rossi: "Let us consider that we are all insane. It will explain us to each other. It will unriddle many riddles." – Mark Twain
- David Rossi: "Man must evolve for all human conflict a method which rejects revenge, aggression, and retaliation. The foundation of such a method is love." – Martin Luther King, Jr.
- Paul Michael Glaser's portrayal of Detective Garrity in the episode marks the only time a director for a Criminal Minds episode has appeared in his own episode (outside of Matthew Gray Gubler, Thomas Gibson, Joe Mantegna, Aisha Tyler, Adam Rodriguez, and AJ Cook appearing as Reid, Hotch, Rossi, Lewis, Alvez, and JJ, respectively, in the episodes they directed).
- The poster seen in this episode later reappears in Brandon Slade's room in "Painless".
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