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- Molly Baker - Jessica Brooks
- Jon Barton - SWAT Leader
- Juan Carlos Cantu - Diego Trejo
- Yvette Cruise - Consuela Ramírez
- Margarita Cordova - Nina Cruz Villanueva
- Juan Jose Dubon - Mexican Prostitute #1
- Presciliana Esparolini - Milagros Villanueva Cruz
- Carlos Gómez - Capitán Víctor Navarro
- Norma Maldonado - District Attorney General María Sánchez
- Meredith Monroe - Haley Hotchner
- Alejandro Patiño - Pablo Vargas
- George Perez - Miguel Trejo
- Margarita Reyes - Ana Santiago
- Giancarlo Robles - Mexican Prostitute #2
- Andres Saenz-Hudson - Roberto González
- Carlos Sanz - Diputado Teniente Bórquez
- Darlena Tejeiro - Rosa Trejo
- Julia Vera - Lupe Trejo
- Andrei Chikatilo, The Rostov Ripper
- Aaron Hotchner: Anthony Brandt wrote, "Other things may change us, but we start and end with family."
- Aaron Hotchner: Mexican proverb: "The house does not rest upon the ground, but upon a woman."
- "Machismo" is a Spanish word for "macho", which means: "a strong sense of masculine pride".
- This episode marks the first of four times the BAU has gone to another country to investigate a case. The others are:
- "To Hell..." and "...And Back" - Where the BAU went to Canada to investigate the Turner Brothers case.
- "Beyond Borders" - Where the BAU and the FBI's International Response Team (IRT) went to Barbados to investigate a family annihilator case
- "Spencer" - The BAU again returns to Mexico with the IRT to investigate Reid's framing.