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- Peanut Alvarez - Stacy
- Jaime Barcelon - Marcus Manning
- Christopher Chen - Doctor Warren Spitz
- Isaac Cheung - Gary
- Kate Connor - Sheryl Timmons
- Mark Gantt - Detective Alex Russ
- Sitara Hewitt - Billie Williams
- Gwen Holloway - Lee-Anne Kelton
- Maria Howell - Doctor Lode Barren
- Calida Jones - Libby
- Jamie Kennedy - Floyd Feylinn Ferell
- Catherine Leong - Johanna Manning
- Shane Paul McGhie - Hunter
- Shemar Moore - Derek Morgan
- Gustavo Quiroz - Jody Buccio
- Isaac C. Singleton, Jr. - Orderly
- Nicole Steinwedell - Lori Buccio
- Ryder Vanias - Hank Spencer Morgan
- "Wilderness" by Taps
- Penelope Garcia: "I like to turn things upside down, to watch pictures and situations from another perspective." – Ursus Wehrli
- David Rossi: "People like to say that the conflict is between good and evil. The real conflict is between truth and lies." – Don Miguel Ruiz
- Although this was the sixth produced episode, it aired as the fifth.
- Christopher Chen, the actor who will portray Doctor Warren Spitz, previously appeared in the Season Ten episode "Burn", in which he played Dan Chen.
- In addition to being a reference to a character, the episode's title is also a reference to the Lucky Strike brand of cigarettes.