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- Lisa Arturo - Debra Wilson
- Jed Bernard - Scott Hartway
- Nicholas Brendon - Analyst Kevin Lynch
- Bill Lee Brown - Alphonse Keppler
- Billy Brown - Coffee Shop Patron
- Sarah Buxton - Leslie Sanders
- Helen Eigenberg - Shirley Andrews
- Thomas Garner - Phil Andrews
- Kathryn Howell - Beth Hartway
- Erin Matthews - Mary-Ann Thomas
- Wayne Nickel - Deacon
- Michelle Parylak - Kathy Hartway
- Juan Pope - Detective David Crowley
- Adrienne Rusk - Female Swinger
- Kiff Scholl - Ben Frelow
- Craig Sheffer - James Thomas
- Mike Smith - Paul Wilson
- Ciel Turich - Male Swinger
- Denise Vasquez - Female Resident
- David Berkowitz, Son of Sam
- Albert Fish, The Gray Man
- Iain Scoular
- Andrei Chikatilo, The Rostov Ripper
- "You're My Everything" by Joe King
- "Disappear (Extended Dub)" by Kitten Control
- "Guise" by Von Iva
- Penelope Garcia: Abraham Lincoln said, "Whatever you are, be a good one."
- Emily Prentiss: "We all wear masks, and the time comes when we cannot remove them without removing our own skin." Andre Berthiaume
- "Compromising position" is a term referring to the act of being caught while in an unexpected sexual act or a position that would leave one open to speculation by others.
- Billy Brown, the actor who portrayed a coffee shop patron, previously appeared in an earlier episode of Criminal Minds, starring as Detective Rick Ware in the Season Two episode "Fear and Loathing."
- Although this was the 4th episode to be aired, it was the 3rd episode to be produced.