Doctor Strange in The Multiverse o Madness - The Loop
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- Kyson Facer - Carl Feinstein
- Brendan Farrell - Cop #1
- Letitia B. Fox - Clarissa Carney
- Laura Leigh Hughes - Mary Cullen
- Alex Jennings - Grace Lynch
- Lennon Kay - Clare Carney
- Sharon Lawrence - Roberta Lynch
- Nick Miller - Damian Carney
- Laura Miranda - Jessica Holden
- Michael Mosley - Everett Lynch
- Gail O'Grady - Krystall Richards
- Alisha Seaton - Monica Feinstein
- Krystall Richards: Stephen King wrote, "The most important things are the hardest to say."
- A.J. Cook is the sixth actor from the show's main cast to direct an episode, the first being Matthew Gray Gubler, the second being Thomas Gibson, the third being Joe Mantegna, the fourth being Aisha Tyler, and the fifth being Adam Rodriguez.
- This is the last episode an actor from the show's main cast directs an episode.
- This is the 8th of 9 episodes in which a non-BAU/ guest cast character, Krystall Richards, recites a bookend quote. The other episodes are:
- "Tabula Rasa" - Ending bookend quote recited by both Mr. Corbett and Spencer Reid.
- "Coda" - Ending bookend quote recited by Ian Doyle.
- "Lauren" - Ending bookend quote recited by JJ (who was with the State Department at that time)
- "Zugzwang" - Ending bookend quote recited by Maeve Donovan.
- "200" - Beginning bookend quote recited by Prentiss. (Who was with Interpol at that time)
- "Beyond Borders" - Ending bookend quote recited by Jack Garrett.
- "Tribute" - Beginning bookend quote recited by Prentiss. (Who was with Interpol at that time)
- "Family Tree" - Beginning and end bookend quote recited by Everett Lynch.