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When the BAU is called to Texas to consult on the murders of prostitutes, evidence points to killings with religious overtones. However, as they delve further into the investigation, the team could put their own lives at risk.
- Roberta E. Bassin - Linda
- Gary Cairns - Travis Henson
- Cici Leah Campbell - Drug Addict
- Tamara Clatterbuck - Dinah Stidham
- Erin Michelle Conroy - Hanna Kelly
- Brett Cullen - Preacher Justin Mills
- Romi Dias - Deputy Vicky Lorenzana
- Ashley Dulaney - Abigail Jones
- Cyrina Fiallo - Jesse Moore
- Brice Fisher - Bobby
- Shawn Law - Albert Franklin
- Aurora Maria Lopez - Erica
- Esai Morales - FBI Section Chief Director Mateo Cruz
- Dougald Park - Principal Andrew McIntyre
- Tom Proctor - Dusty
- Veronica Roy - Belinda Clark
- Amy Schloerb - Carrie Lawson
- Brady Smith - Deputy Marty Bennett
- Sarah Stouffer - Tabitha Ryerson
- Michael Trucco - Deputy Owen McGregor
- Kevin E. West - Sheriff Peter Coleman
- "My World" by Waylon Jennings
- "Famous Faces" by 7Horse
- "Fairlane" by The Dirty Guv'Nahs
- David Rossi: "The name written on her forehead was a mystery: Babylon the Great, the mother of prostitutes and of the abominations of the Earth." — Revelation 17:5
- This episode is the second in the show's history to have more than two writers working on it, with the first being "100", which was written by "Bo Crese", an acronym of Breen Frazier, Oanh Ly, Chris Mundy, Rick Dunkle, Erica Messer, Simon Mirren, and Edward Allen Bernero (all of the members of the writing team for Season Five, the season "100" was produced for).
- Cici Leah Campbell, the actor who portrays a drug addict, previously appeared on Criminal Minds, starring as a victim of John Myers in the Season Eight premiere episode "The Silencer", and as Tina in "The Gathering", another episode in the same season.
- The titles of the two episode parts, "Angels" and "Demons," is possibly a reference to the Dan Brown novel Angels and Demons, the book where the character Robert Langdon was first introduced
- Credited as "Tabitha Ryan"