- Miles Anderson - Doctor Lawrence Nichols
- Jon Barton - SWAT Leader
- Traci Bellusci - Melinda
- David Dean Bottrell - Chad Brown
- Eric Brandon - Ethan
- Samuel Child - Jason
- Andrew Gonzales - Danny
- Joe Holt - Jack Summers
- Joe Howard - Russ Daniels
- Dan Lauria - General Lee Whitworth, M.D.
- Donald Sage Mackay - Senator Baylor
- Chuck Madden - DOD Man
- Elizabeth Maxwell - Abby
- Penny L. Moore - Trudy
- Shaun Paul Piccinino - Quarterback
- Katie M. Roberts - ER Nurse
- Douglas Sutherland - Commuter #2
- Leslie Thurston - Lisa
- Tamlyn Tomita - Doctor Linda Kimura
- Spencer Reid: "It will become fine dust over all the land of Egypt, and will become boils breaking out with sores on man and beast through all the land of Egypt." - Exodus 9:9
- Spencer Reid: "Security is mostly a superstition. It does not exist in nature, nor do the children of men as a whole experience it." - Helen Keller
- ↑ Credited as "Commuter #1"
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