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- Daniella Alonso - Lisa Douglas
- Brian Appel - Agent Grant Anderson
- Karen David - Special Agent Mary Meadows
- Stafford Douglas - Theo Holston
- Randy Evans - Armed Guard
- Michael Hogan - Benjamin David Merva
- James Urbaniak - Special Agent Owen Quinn
- "Through the Fire (feat. Margot Todd)" by Jake Etheridge
- Emily Prentiss: "The only thing new in the world is the history you do not know." – Harry Truman
- Penelope Garcia: "The family, that dear octopus from whose tentacles we never quite escape, nor in our innermost hearts never quite wish to." – Dodie Smith
- 300's air-date of October 3, 2018, marks the second time a season for the show has premiered in a month other than September; the first time was the Season Ten Premiere "X".
- Guest star Michael Hogan played Gerald Argent on Teen Wolf, and one of the writers of this episode, Jeff Davis, is the creator of Teen Wolf.